Psychiatr Serv 59:475, May 2008
doi: 10.1176/appi.ps.59.5.475
© 2008 American Psychiatric Association
May 2008: This Month's Highlights
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Special Section: Interpretingthe CATIE Findings
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In September 2005 the initial report of findings from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) indicated that costly second-generation antipsychotics were no more effective than a first-generation agent. Advocacy groups despaired that these findings would buttress attempts to limit access to the newer agents, and much debate has since ensued about how best to interpret these findings in everyday practice. A special section of nine articles in this month's issue offers clinicians and other stakeholders some much-needed neutral commentary—free of the "thinly veiled industry spin" that has characterized much of the debate about the CATIE findings, according to Marvin S. Swartz, M.D., who served as guest editor of the special section. The first article provides an overview of the CATIE design and main outcomes (page 500). The second article reports results of an analysis of national data to determine trends over ten years in first- and second-generation antipsychotic use and changes in user characteristics (page 507). The third article discusses the intersection of the science of cost-effectiveness with policy and political decision making in regard to CATIE and suggests methods to better align formularies with evidence from cost-effectiveness studies (page 515). The fourth article, a commentary, urges caution on use of CATIE as the cornerstone of new formulary policies (page 521). The fifth article examines take-home lessons from CATIE, underscoring the importance of approaches to prescribing that optimize individual benefit-risk profiles (page 523). The authors of the sixth article discuss CATIE implications from the perspective of mental health services researchers, eschewing interpretations that would support "fail-first" formulary policies (page 526). In the seventh article, a clinical researcher from the United Kingdom welcomes the eroding distinction between first- and second-class agents and the end of the preferred status of the newer drugs (page 530). The final two articles summarize perspectives of two other stakeholder groups—state mental health policy makers (page 534) and patient advocacy groups (page 537). As Dr. Swartz notes in his introduction to the special section (page 497) the most enduring lesson from CATIE "is the need to critically and dispassionately evaluate unbiased empirical data and use the best tools available to drive evidence-based policy and practice." In addition, during the past six months when the special section was in review, the journal accepted three reports on trends in antipsychotic use in the era of second-generation agents—one from the United States (page 540), one from Canada (page 547), and one from the Netherlands (page 554)—reflecting the ongoing and international focus on this important issue.
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Aligning Science and Recovery in Schizophrenia
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The lead article, by several influential thinkers and researchers in the field of schizophrenia treatment, shows how two models of this disease—the "broken brain" model and the "recovery" model—are not as contradictory as they might seem. Jeffrey A. Lieberman, M.D., and coauthors note that the tension between neuroscientists' emphasis on brain pathologies and advocates' emphasis on recovery arises from lack of definitional clarity. They suggest defining recovery in terms of a range of improvements in specific domains, such as "recovery of cognitive functioning" or "recovery of vocational functioning," which will permit clinicians to communicate more clearly regarding research findings and treatment goals. The article examines and links new findings in neurobiology and recovery. The authors conclude that "an operational definition of recovery allows for bridging hope and recovery with important advances in the science of the brain" (page 487).
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Mental Health Services in Europe
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In this issue the journal introduces a column focusing on mental health care reforms in Europe. Matt Muijen, M.D., Ph.D., who is regional adviser for mental health for the World Health Organization's Regional Office for Europe, is column editor. In his introductory installment, Dr. Muijen provides an overview of changes in services across Europe, largely driven by political commitment at national and intergovernmental levels in response to public health challenges posed by mental health problems. He emphasizes the wide diversity across Europe, which includes highly developed Western European countries and former Soviet Union republics, and the urgent need for comparable data (page 479). A brief report by Stefan Priebe, Dr.Med.Habil., and colleagues presents data that appear to indicate an increase in institutional care across nine European countries (page 570). In a commentary, Dr. Muijen urges caution in interpreting these data (page 574).
Related Articles:
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Focus on Mental Health Care Reforms in Europe: Mental Health Services in Europe: An Overview
- Matt Muijen
Psychiatr Serv 2008 59: 479-482.
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Science and Recovery in Schizophrenia
- Jeffrey A. Lieberman, Robert E. Drake, Lloyd I. Sederer, Aysenil Belger, Richard Keefe, Diana Perkins, and Scott Stroup
Psychiatr Serv 2008 59: 487-496.
[Abstract]
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Introduction to the CATIE Special Section
- Marvin S. Swartz
Psychiatr Serv 2008 59: 497-499.
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What CATIE Found: Results From the Schizophrenia Trial
- Marvin S. Swartz, T. Scott Stroup, Joseph P. McEvoy, Sonia M. Davis, Robert A. Rosenheck, Richard S. E. Keefe, John K. Hsiao, and Jeffrey A. Lieberman
Psychiatr Serv 2008 59: 500-506.
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Who Are the New Users of Antipsychotic Medications?
- Marisa Elena Domino and Marvin S. Swartz
Psychiatr Serv 2008 59: 507-514.
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Second-Generation Antipsychotics: Cost-Effectiveness, Policy Options, and Political Decision Making
- Robert A. Rosenheck, Douglas L. Leslie, and Jalpa A. Doshi
Psychiatr Serv 2008 59: 515-520.
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Policy Toward Second-Generation Antipsychotic Drugs: A Cautionary Note
- Richard G. Frank
Psychiatr Serv 2008 59: 521-522.
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Lessons to Take Home From CATIE
- William T. Carpenter and Robert W. Buchanan
Psychiatr Serv 2008 59: 523-525.
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Implications of CATIE for Mental Health Services Researchers
- Nancy H. Covell, Molly T. Finnerty, and Susan M. Essock
Psychiatr Serv 2008 59: 526-529.
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What CATIE Did: Some Thoughts on Implications Deep and Wide
- David Cunningham Owens
Psychiatr Serv 2008 59: 530-533.
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Impact of the CATIE Findings on State Mental Health Policy
- Joseph J. Parks, Alan Q. Radke, and Rajiv Tandon
Psychiatr Serv 2008 59: 534-536.
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NAMI Perspective on CATIE: Policy and Research Implications
- Kenneth Duckworth and Michael J. Fitzpatrick
Psychiatr Serv 2008 59: 537-539.
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Effect of Prior Authorization of Second-Generation Antipsychotic Agents on Pharmacy Utilization and Reimbursements
- Michael R. Law, Dennis Ross-Degnan, and Stephen B. Soumerai
Psychiatr Serv 2008 59: 540-546.
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Utilization and Costs of Antipsychotic Agents: A Canadian Population-Based Study, 1996–2006
- Silvia Alessi-Severini, Robert G. Biscontri, David M. Collins, Anita Kozyrskyj, Jitender Sareen, and Murray W. Enns
Psychiatr Serv 2008 59: 547-553.
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Use of Antipsychotic Drugs Among Dutch Youths Between 1997 and 2005
- Luuk J. Kalverdijk, Hilde Tobi, Paul B. van den Berg, Janelle Buiskool, Leonie Wagenaar, Ruud B. Minderaa, and Lolkje T. W. de Jong-van den Berg
Psychiatr Serv 2008 59: 554-560.
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Mental Health Care Institutions in Nine European Countries, 2002 to 2006
- Stefan Priebe, Patrick Frottier, Andrea Gaddini, Reinhold Kilian, Christoph Lauber, Rafael Martínez-Leal, Povl Munk-Jørgensen, Dermot Walsh, Durk Wiersma, and Donna Wright
Psychiatr Serv 2008 59: 570-573.
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Commentary: Interpreting Data on "Institutionalization": Not Simply Counting Beds
- Matt Muijen
Psychiatr Serv 2008 59: 574.
[Full Text]
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