Psychiatr Serv 59:315-317, March 2008
doi: 10.1176/appi.ps.59.3.315
© 2008 American Psychiatric Association
Time to Discontinuation of Depot and Oral First-Generation Antipsychotics in the Usual Care of Schizophrenia
Baojin Zhu, Ph.D.,
Haya Ascher-Svanum, Ph.D.,
Lizheng Shi, Ph.D.,
Douglas Faries, Ph.D.,
William Montgomery, B.Pharm. and
Stephen R. Marder, M.D.
OBJECTIVE: This study compared the time to discontinuation for any reason of first-generation antipsychotics—in oral versus depot formulation—in the usual care of schizophrenia. METHODS: This study used data from a three-year, prospective, nonrandomized, noninterventional, multisite study of schizophrenia. Participants initiated on oral haloperidol or fluphenazine (N=202) were compared with those initiated on haloperidol or fluphenazine in depot formulation (N=97) on time to all-cause discontinuation for one year after initiation, by using Kaplan-Meier survival analysis, a Cox proportional hazards regression model, and propensity score-adjusted bootstrap resampling methods. RESULTS: Compared with participants treated with the oral formulation, those treated with depot first-generation antipsychotics had a significantly longer mean time to all-cause medication discontinuation and were twice as likely to stay on the medication. CONCLUSION: In the usual care of schizophrenia, treatment with first-generation antipsychotics in depot formulation appears to be associated with longer time to all-cause medication discontinuation compared with oral formulation of the same medication.
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